Inhibition of Cetylpyridinium Chloride against the Growth of Porphyromonas gingivalis
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Abstract
Periodontal disease is a prevalent dental and oral health issue within the community, typically commencing with symptoms of gingivitis and potentially advancing to periodontitis. Porphyromonas gingivalis is an obligate anaerobic Gram-negative bacterium that is the primary aetiological agent in developing periodontal disease. One strategy to avert periodontal disease is the utilization of antibacterial medicines such as cetylpyridinium chloride. This study seeks to evaluate the inhibitory efficacy of cetylpyridinium chloride against Porphyromonas gingivalis. The in vitro inhibitory efficacy of cetylpyridinium chloride against Porphyromonas gingivalis was assessed using the colony count method and compared to the positive control, Chlorhexidine. The percentage of inhibition for each concentration was determined to ascertain the minimal inhibitory and bactericidal concentrations. The minimum inhibitory concentration of cetylpyridinium chloride was 92.66% at a concentration of 0.05% and >99.9% at 0.06%. Cetylpyridinium chloride effectively inhibits the development of Porphyromonas gingivalis bacteria at a concentration of 0.05% with a MIC value of 92.66%. These results indicate that cetylpyridinium chloride shows significant antibacterial activity against Porphyromonas gingivalis, suggesting its potential as an effective agent in preventing and managing periodontal disease.
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