Tropical Journal of Natural Product Research (TJNPR) is the official scientific publication of the Natural Product Research group, University of Benin; and it is available in both printed and electronic formats. The journal is published monthly.

Tropical Journal of Natural Product Research (TJNPR) is a peer-reviewed, open access online international journal which publishes original research papers. The journal welcomes submission from scholars and experts for possible publication from all over the world. The scope of the journal includes: Pharmaceutical research, chemistry and biochemistry of naturally occurring compounds, biological evaluation of crude extracts, ethnomedicine, traditional and complementary medicine, ethnopharmacology, biomedical research, Biotechnology, Evaluation of natural substances of land and sea and of plants, microbes and animals, pharmacognosy, bioavailability, clinical, pharmacological, toxicological studies and pharmacokinetics of phytochemicals, Isolation and characterization of compounds, structure elucidation, synthesis and experimental biosynthesis of natural Product as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, papers discussing the screening of natural Product for biological activity against different health targets are also encouraged.

Current Issue

Vol. 9 No. 2 (2025): Tropical Journal of Natural Product Research (TJNPR)

Published: 2025-02-28

Articles

Antihyperlipidemic Effects of Stevia rebaudiana Bertoni: A Review

Tropical Journal of Natural Product Research

Jessica Febrina, I Made Muliarta, Ida Ayu Ika Wahyuniari

415-423

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DOI: https://doi.org/10.26538/tjnpr/v9i2.1

The Potential Role of Saffron Extract, Crocin, and Crocetin in Modulating TNF- And IL-6 Levels in Various Diseases: A Review

Tropical Journal of Natural Product Research

Lani Ishak, Diana K. Jasaputral, Julia W. Gunadi, Lukas M. Samuel, Rizna T. Rumanti

424-431

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DOI: https://doi.org/10.26538/tjnpr/v9i2.2

The Potential Use of Rosmarinus officinalis L. as Antinociceptive Agent: A Systematic Review

Tropical Journal of Natural Product Research

Husnul Khotimah, Dita N. Azizah, Widy Jatmiko, Azkiya A. Rahmaniar, Siti Istiana, Intan Katili, Yuli Nugraeni, Ranny Rachmawati, Buyung H. Laksono

432-438

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DOI: https://doi.org/10.26538/tjnpr/v9i2.3

In Silico Prediction of Anti-Inflammatory Potential of Isolated Compounds from Enhalus acoroides

Tropical Journal of Natural Product Research

Thuy X. Ho, Tuan N. Nguyen, Hang T.T. Tran, Tram T.T. Nguyen, Idania Rodeiro Guerrae, Phuong L. Doan, Thang D. Tran

439-446

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DOI: https://doi.org/10.26538/tjnpr/v9i2.4

Evaluation of Membrane Stabilizing, Thrombolytic, Anti-Diarrheal and Antipyretic Activities of Ethanolic Extracts of Hoya Parasitica variegata and Crotalaria pallida Aiton

Tropical Journal of Natural Product Research

Israt J Bulbul, Afifa P Shanta, Mirza P Mahmud, Nisrat Jahan, Zebunnesa Ahmed

447-453

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DOI: https://doi.org/10.26538/tjnpr/v9i2.5

Potential of Nanoencapsulated Curcuma longa-Andrographis paniculata as an Anticancer Agent

Tropical Journal of Natural Product Research

Sari E. Cahyaningrum, Andika P. Wardana, Fitriari I. Muhaimin, Amalia P. Purnamasari, Browi Nugroho, Misni B. Misran

454-459

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DOI: https://doi.org/10.26538/tjnpr/v9i2.6

Inhibition of Dehydrogenase Activity in Sputum Bacterial Isolates by hot aqueous extracts of selected Nigeria anti-cough plants

Tropical Journal of Natural Product Research

Olachi L. Osuagwu, Chidi U. Igwe, Chiamaka P. Nzebude, Chinaza S. Dike , Chukwudubem A. Morah, Njideka W. Nsofor,  Onyinyechi C. Njoku

460-466

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DOI: https://doi.org/10.26538/tjnpr/v9i2.7

Experimental Models Of Metabolic Syndrome In Male Wistar Rats

Tropical Journal of Natural Product Research

Evy Sulistyoningrum, Asri Hendrawati, Dede S.I Aulia

467-472

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DOI: https://doi.org/10.26538/tjnpr/v9i2.8

Simultaneous Analysis Method for Rutin, Diosmin, Hesperidin, and Quercetin in Solid Food Supplements by HPLC-PDA

Tropical Journal of Natural Product Research

Thu T.A. Bui, Minh T.T. Do, Son T.T. Do, Thinh T. Nguyen, Chung D. Duong

473-479

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DOI: https://doi.org/10.26538/tjnpr/v9i2.9

Optimization and Characterization of Dayak Onion (Eleutherine palmifolia (L.) Merr) Extract Nanoparticles Using Cross-link Method

Tropical Journal of Natural Product Research

Rahmi Annisa, Ria Indah Lestari, Shophy Salsabil Aqila, Cecelia Tsania Fanany, Avin Ainur Fitrianingsih, Ermin Rachmawati, Nabila Rahmadiani, Roihatul Muti’ah

480-486

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DOI: https://doi.org/10.26538/tjnpr/v9i2.10

Chemical Profiling and Antioxidant Capacity Assessment of Three Endemic Thymus Species Distributed in Bulgaria

Denitsa K. Kancheva, Milena T. Nikolova, Ina Y. Aneva

487 - 494

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DOI: https://doi.org/10.26538/tjnpr/v9i2.11

Cytotoxicity of Blumea balsamifera on A549 Lung Cancer Cells: Integrating in Vitro Analysis with Computational Study of AKT-1 Inhibition

Friska A Nurlailiyah, Dinia R Dwijayanti, Feri E Hermanto, Masruri Masruri, Nashi Widodo

495 - 503

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DOI: https://doi.org/10.26538/tjnpr/v9i2.12

Prediction of Antiinflammatory Effects of Rosmarinus officinalis L. in Osteoarthritis Through Inhibition in PGE2-R, COX-2, and IL-1b: an In Silico Study

Husnul Khotimah, Hartiyo L Buyung, Siti Istiana, Intan Katili, Widy Jatmiko

504 - 511

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DOI: https://doi.org/10.26538/tjnpr/v9i2.13

Antioxidant Properties of Parquetina nigrescens Methanol Leaf Extract Ameliorates Arsenic-Induced Reproductive Functions Alteration in Male Wistar Rats

Oore-oluwapo O. Daramola, Wahab A. Oyeyemi, Adeniran O. Akinola, Yinusa Raji

513 - 519

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DOI: https://doi.org/10.26538/tjnpr/v9i2.14

In vitro Pharmacological Evaluation of Herbal Tea for the Treatment of Urolithiasis

Ravishankar Ram Mani, Angeline KP Lynn, Venkatalakshmi Ranganathan, Jithendra Panneerselvam, Sasikala Chinnappan

520 - 526

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DOI: https://doi.org/10.26538/tjnpr/v9i2.15

Effects of Solvent Type and Simplicia-to-Solvent Ratio on the Phenolics, Flavonoids, and Antioxidant Activity of Torch Ginger (Etlingera elatior) Fruit

Yayu M Evary, Muhammad N Amir, Muhammad Raihan, Dewi P Laela

527 – 533

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DOI: https://doi.org/10.26538/tjnpr/v9i2.16

In vitro and In silico study of antioxidants and anti-inflammatory activity of bitter leaves (Vernonia amygdalina del.) Extract

Ernie Halimatushadyah, Illah Sailah, Trina Ekawati Tallei, Yulianida Tamala, Linda Safitri, Aji Humaedi

534 – 540

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DOI: https://doi.org/10.26538/tjnpr/v9i2.17

Evaluation of Oxidative Stress Levels in Codeine-Induced and Codeine Recovery Phase of Albino Rats

Chiagozie C King-Bertram, Esther I Etu, Nyejirime Y Wike, Achi U Franklyn, Ukamaka P Obichukwu-Ehighibe, Ndubuisi N Richards, Chinedu P Maduka, Chukwu D Chigozie, Ekoh, J Adaorah, Chinonso C Ani, Afun I Olabanji, Emmanuel A Ameh, Maria C Ugwuodo, Omolola M Stephen , Ngozi R Esenwa

541 – 544

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DOI: https://doi.org/10.26538/tjnpr/v9i2.18

In Vitro and in Silico Analysis of Antilipase, Antioxidant, and Optimization of Granule Effervescent from Peronema canescens Jack

Muhammad R. R. Rahardhian, Nurchasanah, Yasmiwar Susilawati, Sri A. Sumiwi, Dewi Ramonah, Dewi Ramonah, Chintiana N. Putri, Ririn Suharsanti

545 – 553

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DOI: https://doi.org/10.26538/tjnpr/v9i2.19

Potential of Cell-Free Fermentation Supernatant from Yellow Passion Fruit Microspheres as a Novel Antibacterial Agent Against Multi-Drug Resistant Organisms

Esti Hendradi, Tutiek Purwanti, Andang Miatmoko, Safarini Marwah, Isnaeni Isnaeni

554 – 560

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DOI: https://doi.org/10.26538/tjnpr/v9i2.20

Assessment of Analgesic, Antioxidant, and Anti-inflammatory potential of Citrus maxima (Burm.) Merr. Seed solvent fractions on Swiss albino Animal Model

Nazratun N. Maria, Namira Jannat, Ummah T. Nisat, Nusrat Jahan, Pritesh R. Dash

561 – 567

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DOI: https://doi.org/10.26538/tjnpr/v9i2.21

Aqueous Extract of Emilia praetermissa Milne-Redh. (Asteraceae) Leaf Attenuates Salt-induced Hypertension in Male Wistar Rats: Biochemical Evidence

Tropical Journal of Natural Product Research

Shirley O. Ebhohon, Frederick O. Obi, Ngozi P. Okolie, Fabian C. Amaechina

568-584

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DOI: https://doi.org/10.26538/tjnpr/v9i2.22

Bibliometric Analysis of Medicinal Plants from Brunei Darussalam: Uncovering Novel Anticancer Targets

Tropical Journal of Natural Product Research

Marcellino Rudyanto, Tri Widiandani, Hadi Poerwono, Mohammad Rizki Fadhil Pratama

585-612

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DOI: https://doi.org/10.26538/tjnpr/v9i2.23

Evaluation of Toxicity and Anticonvulsant Activities of Solanum torvum Sw., Fruits

Tropical Journal of Natural Product Research

Vaddi A N V Harita, Soumitra Sahana, Sumanta Mondal

613-627

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DOI: https://doi.org/10.26538/tjnpr/v9i2.24

Differences in the Effects of Arcangelisia flava and Taxus sumatrana Extracts on Mice Skin (Mus musculus) ageing Induced by D-Galactose

Tropical Journal of Natural Product Research

Biomechy Oktomalioputri, Noverial, Rayhand, Dwisari Dillasamola

628-631

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DOI: https://doi.org/10.26538/tjnpr/v9i2.25

Total Sugar Content and Antioxidant Activity of Nipa Palm (Nypa fruticans) Fruit Husk Oligosaccharides

Tropical Journal of Natural Product Research

Herpandi, Edwinsyah P. Saputra, Gama D. Nugroho, Indah Widiastuti, Miftahul Janna, Sabri Sudirman

632-635

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DOI: https://doi.org/10.26538/tjnpr/v9i2.26

The Effect of Pomegranate Peel (Punica granatum L.) Extract in Chitosan Nanoparticle on the Macrophage Polarization in DSS-Induced Mice

Tropical Journal of Natural Product Research

Yogia Ikhsas, Kusmardi Kusmardi, Ria Kodariah, Fatiha Kamilah

636-641

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DOI: https://doi.org/10.26538/tjnpr/v9i2.27

Evaluation of Osteoblast and Fibroblast Viability on Bovine Amniotic Membrane

Tropical Journal of Natural Product Research

Noer Ulfah, Ernie M. Setiawatie, Lambang Bargowo, Shafira K. Supandi, Dewina M. Larasati, Esi Y. Fitrina, I Gusti Agung A. Putra, Diajeng K. D. Sekartaji, Ken R. Sayidinar

642-645

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DOI: https://doi.org/10.26538/tjnpr/v9i2.28

Momordica charantia Leaf Extract Attenuates Cyanide Toxicity by Enhancing Antioxidant, Anti-inflammatory and Cholinergic response in Rats’ Brain

Tropical Journal of Natural Product Research

Emmanuel S. Akintimehin, Kayode O. Karigidi, David N. Charles, Adeoluwa P. Ibijola, Foluso O. Adetuyi

646-652

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DOI: https://doi.org/10.26538/tjnpr/v9i2.29

Comprehensive Quality Assessment of Dittrichia viscosa (L.) from Southeast Morocco: Physicochemical Properties, Phytochemical Composition, Microbiological Profile and Mineral Content Analysis

Tropical Journal of Natural Product Research

Rania Jerada, Abdelmoula El Ouardi, Rachid Ben Aakame, Abdeljalil Er-Rakibi Rakibi, Najia Ameur, Rim Bougassa, Achraf Hamik, Nour-Eddine Loud, Hanane Benzeid, Brahim Mojemmi, Anass Doukkali

653-663

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DOI: https://doi.org/10.26538/tjnpr/v9i2.30

Effect of Kaempferia galanga L. on Xanthine Oxidase Activity and Arterial Stiffness in Hyperuricemia

Patonah Hasimun, Yoga A. R. Muzaki, Jajang J. Sodik, Ika K. Sukmawati, Herni Kusriani

664 – 669

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DOI: https://doi.org/10.26538/tjnpr/v9i2.31

Enhanced Extraction of Antishigellosis Compounds from Ficus elastica Leaves: A Response Surface Methodology Approach

Kusuma Af Sri, Hannifah N. Kamiliyah, Dudi Runadi 

670 – 676

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DOI: https://doi.org/10.26538/tjnpr/v9i2.32

Cost-Effectiveness Analysis of Antihypertensive Drugs in Hypertensive Patients with Diabetes Mellitus Comorbidity in Inpatient Patients of Bengkulu Province, Indonesia

Riani Tanjung, Yulia Wardati, Ida E. Widiyawati, Indra Permana, Chendy F. Ningsih, Evin E. Julita, Nyi M. Saptarini

677 – 684

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DOI: https://doi.org/10.26538/tjnpr/v9i2.33

Monodora Myristica Seed Extract Mitigates Lead Acetate Induced Hepatic and Testicular Injury in Male Wistar Rats

Tropical Journal of Natural Product Research

Ikponmwosa Aikpitanyi, Maureen I. Ebomoyi

685-690

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DOI: https://doi.org/10.26538/tjnpr/v9i2.34

From Healing to Harm: Exploring Moroccan Herbalists' Insight Into the Nephrotoxicity and Cancer Threats of Aristolochiaceae

Tropical Journal of Natural Product Research

Hind Khalil, Nour El Houda Benkaddour, El Mahdi Razzok, Asmae Lekfif, Naima Abda, Yassamine Bentata

691-697

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DOI: https://doi.org/10.26538/tjnpr/v9i2.35

Gingival Recession In The Periodontology Specialist Polyclinic Of The Oral And Dental Hospital, Airlangga University, From January To December 2022

Tropical Journal of Natural Product Research

Shafira K. Supandi, Lambang Bargowo, Irma J. Savitri, I Gusti Agung A Putra, Adendra A. Fathurrahman, Azzahra H. Islamy

698-701

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DOI: https://doi.org/10.26538/tjnpr/v9i2.36

Discovering the Potential Mechanisms of Canna indica Leaves Ethanolic Extract against Plasmodium falciparum Malaria: Network Pharmacology and Molecular Docking Approach

Tropical Journal of Natural Product Research

Kana Mardhiyyah, Christopher K. Johan, Eurica A. N. Ravsanjani

702-710

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DOI: https://doi.org/10.26538/tjnpr/v9i2.37

The Effect of Solvents and Extraction Techniques on the Quality of Mangrove Crab Shells Gelatin (Scylla serrata)

Tropical Journal of Natural Product Research

La Ode A. Rasydy, Zenith P. Dewianti, Syifa S. Hayatunnisa, Adefia Femalda, La Ode M. Anwar, Fikria M. Nur, Lulu L. Octaviani, Nadianti P. Della

711-715

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DOI: https://doi.org/10.26538/tjnpr/v9i2.38

n-Hexane Extract of Leptastrea purpurea: Antioxidant Activity in Vitro and in Silico

Tropical Journal of Natural Product Research

Haryanto Susanto, Nashi Widodo, Masruri Masruri, Siti Mariyah Ulfa, Rollando Rollando

716-727

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DOI: https://doi.org/10.26538/tjnpr/v9i2.39

Effect of Ethanol Extract of Amaranthus Viridis (Inine) on Potassium-Bromide-Induced Haematoxicity in Wistar Rats

Tropical Journal of Natural Product Research

Innocent I. Ujah, Godwin S. Alor, Cosmas E. Achikanu, Onuabuchi N. Ani, Chukwunonso A.  Nsude, Uchenna B. Alozieuwa, Jane I. Ugochukwu, Ebere I. Akpata, Justice C. Ude, Kenechukwu C. Onyishi, Innocent O. Okpako, Chukwuemeka O. Okechukwu, Obiora E. Nneji, Chikezie K. Ogbu, Chinenye A. Anieke, Onyebuchi P. Ogbodo

728-733

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DOI: https://doi.org/10.26538/tjnpr/v9i2.40

The Impact of Mining on Antioxidant Activity and Nutritional Composition of Zea mays in Edo North, Edo State, Nigeria

M. Imade Eseigbe, Usunobun Usunomena

734-740

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DOI: https://doi.org/10.26538/tjnpr/v9i2.41

Antioxidant Properties of Parquetina nigrescens Methanol Leaf Extract Ameliorates Arsenic-Induced Reproductive Functions Alteration in Male Wistar Rats

Tropical Journal of Natural Product Research

Oore-oluwapo O. Daramola, Wahab A. Oyeyemi, Adeniran O. Akinola, Yinusa Raji

741-747

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DOI: https://doi.org/10.26538/tjnpr/v9i2.42

The comparison of antioxidant properties between frozen and freeze-dried strawberries (Fragaria x ananassa)

Tropical Journal of Natural Product Research

Ardyarini D. Savitri, Sony Wibisono, Siswandono, Akbar R Muhammad, Soetjipto

748-755

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DOI: https://doi.org/10.26538/tjnpr/v9i2.43

Anticancer Activity of Leaf Extracts and Fractions of Etlingera elatior (Jack) R.M.Sm. from North Luwu, Indonesia, using the MTT Assay Protocol

Tropical Journal of Natural Product Research

Yuri P. Utami, Risfah Yulianty, Yulia Y. Djabir, Gemini Alam

756-764

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DOI: https://doi.org/10.26538/tjnpr/v9i2.44

Potential Antiplasmodial Activity of Artemether and Miconazole Combination against Plasmodium berghei in Preclinical Murine Malaria Model

Tropical Journal of Natural Product Research

Franklin C. Kenechukwu; Angela C. Ani, Goodluck O. Anyanwu, Godwin C. Chukwu, Bonaventure A. Odo, Tochukwu P. Odoh, Mary U. Obila, Linda C. Nweke, Ezichi F. Nzekwe, Jude E. Ogbonna, Wilfred I. Ugwuoke, Mumuni A. Momoh, Anthony A. Attama

765-775

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DOI: https://doi.org/10.26538/tjnpr/v9i2.45

Analysis of herbal poultices for knee pain relief in hospitals in the Office of the Permanent Secretary, Ministry of Public Health, Thailand

Tropical Journal of Natural Product Research

Aumpol Bunpean, Noppcha Singweratham

776-781

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DOI: https://doi.org/10.26538/tjnpr/v9i2.46

Formulation of Lecithin-Based Nanocapsules of Levofloxacin and In Vitro Evaluation of the Anti-Mycobacterium Potentials

Chekwube A. Ezegbe, Chukwuemeka C. Mbah, Amarachi G. Ezegbe, Ifeanyi S. Ofoefule

782 – 795

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DOI: https://doi.org/10.26538/tjnpr/v9i2.47

Phytochemicals and Antioxidant Properties of Ethanol Extract of Terap Fruit Seeds (Artocarpus odoratissimus)

Ika Yulianti, Doris Noviani, Titik T. Ismandari, Aditya Murtilaksono, Ririn Ariyanti
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DOI: https://doi.org/10.26538/tjnpr/v9i2.48

Anti-inflammatory Activity and GC-MS Investigation of an Extract of Capsicum chinense (Var. Nsukka Yellow Pepper) Fruit

Vincent O. Chukwube, Patience N. Ugwu, Chinenyenwa P. Osigwe, Nonhlagabezo Maduba, Eleje O. Okonta, Charity C. Ezea, Fabian I. Eze, Charles O. Nnadi, Uchenna E. Odo

804 – 810

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DOI: https://doi.org/10.26538/tjnpr/v9i2.49

In vitro Inhibitory Activity of Bacillus amyloliquefaciens Isolates against Botrytis cinerea Mycelial Growth and Determination of the Minimal Inhibitory Concentration

Ahlem Hamdache, Anass Ben Moula, Ahmed Bagayou, Mohamed Mchita, Mohammed Ezziyyani 

811 – 816

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DOI: https://doi.org/10.26538/tjnpr/v9i2.50

In Silico and Multivariate Analysis of Herbal Compounds in Asthma Inflammation: Exploring Alternatives to Corticosteroids

Ayu K. A. Gunawan, Putu S. Yustiantara, Pande M. N. A. Sari, Dyah K. Wati, Masteria Y. Putra, M. A. G. Wirasuta

817 – 825

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DOI: https://doi.org/10.26538/tjnpr/v9i2.51

In Vitro Evaluation of Stem Extracts and Essential Oils from Sawdust of Cedrus atlantica (Endl.) G. Manetti ex Carrière for their Photoprotective and Antihyperglycemic Activities

Mouna Ameggouz, Soufiane Drioua, Otman El-Guourrami, Hanane Azalmad, Khairo El Baria Metni, Ahmed Zahidi, Anass Doukkali, Badr Satrani, Hanane Benzeid

826 – 832

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DOI: https://doi.org/10.26538/tjnpr/v9i2.52

Aqueous Leaf Extracts of Lasianthera africana: Antibacterial activity, Acute Toxicity Testing, Effect on Gastrointestinal Microbiota and CD4+ T-lymphocyte Values of Wistar Rats Infected with Extensively Drug Resistant-Salmonella typhi

Olajide J. Akinjogunla, Ayodele O. Ajayi, Mfonido I. Okon, Ngozichukwu G. Uzoewulu, Edith E. Chukwu, David E. Ukem, Uduak H. Usoro, Ephraim S. Peter, Karen S. Paul

833 – 845

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DOI: https://doi.org/10.26538/tjnpr/v9i2.53

Evaluation of Garcinia cowa Leaf Extract as A Potential Anticancer Agent: Cytotoxicity, Selectivity, and Apoptotic Effects on MCF-7/HER-2 Cells

Mainal Furqan, Fatma S. Wahyuni, Meri Susanti, Dachriyanus Hamidi

846 – 852

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DOI: https://doi.org/10.26538/tjnpr/v9i2.54
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