Antioxidant Potentials of Terminalia catappa Seed Extract and Metformin on the Liver and Kidney of Diabetic Wistar Rats

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Published: 2025-05-31
DOI: https://doi.org/10.26538/tjnpr/v9i5.26
Keywords:
Antioxidant potential, Terminalia catappa, Metformin, Liver tissues, Kidney tissues, Diabetic Wistar rat

Main Article Content

Catherine IO Ukam
Department of Biochemistry, College of Medical Sciences, University of Calabar Nigeria
Ugochukwu G Jidere
Department of Biochemistry, College of Medical Sciences, University of Calabar Nigeria
Josephine E. Egbung
Department of Public Health, University of Calabar, Calabar, Nigeria
Magdalene Obiabang
Department of Biochemistry, Faculty of Physical Science, University of Cross River State, Nigeria
Daniel E Uti
Department of Research and Publications, Kampala International University, P.O. Box 20000, Kampala, Uganda
Item J Atangwho
Department of Biochemistry, College of Medical Sciences, University of Calabar Nigeria
Godwin E Egbung
Department of Biochemistry, College of Medical Sciences, University of Calabar Nigeria

Abstract

The antioxidant effects of Terminalia catappa ethanol seed extract in the liver and kidneys of diabetic Wistar rats induced with streptozotocin was investigated. Thirty rats weighing 140 g – 180 g were randomly divided into five treatment groups. The normal control (NC) and 50 mg/kg b.w streptozotocin-induced diabetic control (DC) groups received placebo, while the treated groups included 500 mg/kg b.w metformin only group (G), 500 mg/kg b.w T. catappa seed extract only group (E) and combined 250 mg/kg b.w dose each of Metformin and T. catappa seed extract (GE). Administration was via oral gavage for 21 days. The animals were sacrificed and the effect on antioxidant enzymes and lipid peroxidation in the kidney and liver tissue homogenates were evaluated. The results obtained showed that treatment with T catappa seed extract and metformin significantly (p<0.05) improved glutathione, (GSH) levels in hepatic tissues in the diabetic rats while no significant effect was observed in the kidneys. Further, renal and hepatic levels of glutathione peroxidase and superoxide dismutase showed significant reduction (p<0.05) in the untreated diabetic group, an observation that was reversed following treatment with T. catappa seed extract and reference drug, metformin. Additionally, treatment with T. catappa and metformin was observed to significantly decrease the levels of malondialdehyde (MDA) in both hepatic and renal tissues. Conclusively, T. catappa has antioxidant activities and is a potential candidate to manage diabetes related oxidative stress.

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Article Details

Issue

Vol. 9 No. 5 (2025): Tropical Journal of Natural Product Research (TJNPR)

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Articles
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Author Biographies

Catherine IO Ukam, Department of Biochemistry, College of Medical Sciences, University of Calabar Nigeria

drironya@unical.edu.ng

Tel.: +2348142279501

Daniel E Uti, Department of Research and Publications, Kampala International University, P.O. Box 20000, Kampala, Uganda

Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, Federal University of Health Sciences, Otukpo, Benue State, Nigeria

How to Cite

Ukam, C. I., Jidere, U. G., Egbung, J. E., Obiabang, M., Uti, D. E., Atangwho, I. J., & Egbung, G. E. (2025). Antioxidant Potentials of Terminalia catappa Seed Extract and Metformin on the Liver and Kidney of Diabetic Wistar Rats. Tropical Journal of Natural Product Research (TJNPR), 9(5), 2061-2066. https://doi.org/10.26538/tjnpr/v9i5.26

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