Justicia gendarussa Gel Film: A New Approach to Alleviating Upper Back Muscle Pain
Article Sidebar
Views | PDF/EPUB Downloads:
211
/ 136
/ 15
Main Article Content
Abstract
The present research aimed to develop a gel film incorporating Justicia gendarussa Burm.f for upper back muscle pain relief. This research and development utilized a survey approach to assess the pain relief needs of the target group, which served as data for developing the Justicia gendarussa gel patch. Stability testing was conducted using the Heat Cooling cycle method for 6 cycles. A pilot study was then carried out, where participants applied the gel patch to the affected area once daily for 7 days. The study found that common issues with traditional pain relief products, such as greasiness and manual application, were mitigated by developing a non-greasy, user-friendly gel film. The formulation included PVA, PVP, triethyl citrate, HPMC, butylene glycol, water, ethanol, and 1% Justicia gendarussa extract, packaged in a durable, acid-resistant polypropylene bottle. The gel film significantly reduced upper back muscle pain, improved neck mobility, and increased pain threshold (p < 0.001). 4) User satisfaction was high, with an average rating of 4.58±0.58. Hence, the results indicate that the Justicia gendarussa gel film provides an innovative and effective approach for managing upper back muscle pain while enhancing patient comfort and satisfaction.
Downloads
Article Details
Section
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
How to Cite
References
1. Longa DM, Henderson FC. Upper back pain. Symptomatic: The Symptom-Based Handbook for Ehlers-Danlos Syndromes and Hypermobility Spectrum Disorders. 1st ed., Elsevier. 2023; 293.
2. Shierly C, Diana L. A review on the bioactivities of Justicia gendarussa. IOP Conf Ser Earth Environ Sci, 2020; 794, 012137.
3. Putri VA, Zulharmita RA, Chandra B. Overview of phytochemical and pharmacological of Gandarussa extract (Justicia gendarussa Burm). EAS J Pharm Pharmacol. 2020; 2(5):180-185.
4. Bunpean A, Jampreecha T, Sansurin N. Effect of Justicia gendarussa Burm. F (kraduk kai dum) oil and Zingiber cassumunar Roxb. (plai) oil massage on neck and shoulder pain from office syndrome. J Thai Trad Alt Med. 2019; 17(1):95-105.
5. Kavitha SK, Helen A. Antirheumatic Potential of Justicia gendarussa Root Extract on Chronic Arthritic Models. 1st ed., A Holistic and Integrated Approach to Lifestyle Diseases: Apple Academic Press 2022.
6. Pünnel LC, Lunter DJ. Film-forming systems for dermal drug delivery. Pharmaceutics. 2021; 13(7):932.
7. Bunpean A, Ounprasertpong NL. Effects of Massage with Plai Juice and Plai Oil on the Relief of Neck and Shoulders Pain: A Study from Kanchanabhishek Institute of Medical and Public Health Technology. South Coll Netw J Nurs Public Health. 2019; 6(1):121-130.
8. Khongsai S, Chalad C, Phumee P. Phytochemical analysis, in vitro screening of antioxidant and antibacterial potential of Cajuput (Melaleuca cajuputi) extract against pathogenic Vibrio spp. Trop J Nat Prod Res. 2024; 8(12): 9517–9523.
9. Annisa R, Agustin YE, Rahmadani N, Mutiah R. Formulation and Characteristics of Film Forming Hydrogel (FFH) of Yellow Root Extract (Arcangelisia Flava (L.) Merr.) As Wound Healing for Burns. Biomed. Pharmacol. J. 2024; 17(3): 1667-1677.
10. Chaiwaree S, Khoothiam K, Thepmalee Ch, Thephinlap Ch, Suwannasom N. Antibacterial Activity of Acorus calamus Linn. and Litsea cubeba (Lour.) Pers. and Their Efficacy in Shower Gel Formulation. Trop J Nat Prod Res. 2021; 5(12):2085-2091
11. Aree T, Kritpet T, Maphong R. The Acute Effects of Different Tuina Time Massage on Work-Related Muscle Pain from Office Syndrome in Office Workers. J. Sports Sci. and Health. 2024; 25(2):118-33.
12. Jackson LM, Schwinn DA. (Eds.). Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. In National Academies Press (US). 2020.
13. Riccio BVF, Silvestre ALP, Meneguin AB, Ribeiro TDC, Klosowski AB, Ferrari PC, Chorilli M. Exploiting polymeric films as a multipurpose drug delivery system: a review. AAPS Pharm Sci Tech. 2022; 23(7):269.
14. Umemura RT, Felisberti MI. Plasticization of poly (3‐hydroxybutyrate) with triethyl citrate: thermal and mechanical properties, morphology, and kinetics of crystallization. J Appl Polym Sci. 2021; 138(10):49990.
15. Zhang Q, Li X, Jasti BR. Role of physicochemical properties of some grades of hydroxypropyl methylcellulose on in vitro mucoadhesion. Int J Pharm. 2021; 609:121218.
16. Pinto JR, Monteiro SA, Leonardi GR. Effects of 1, 3‐propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function. Int J Cosmet Sci. 2024; 46(1):85-95.
17. Borges A, José H, Homem V, Simões M. Comparison of Techniques and Solvents on the Antimicrobial and Antioxidant Potential of Extracts from Acacia dealbata and Olea europaea. Antibiotics. 2020; 9(2):48.
18. Ali MF, Mahmud S, Mohiuddin RB, Chowdhury K, Mohiuddin AKM. Screening of Preliminary Phytochemicals, Molecular Identification, and Antimicrobial and Anti‐Inflammatory Activity of Justicia gendarussa. Evid Based Complement Alternat Med. 2023; 2023(1):6885353.
19. Benyathiar P, Kumar P, Carpenter G, Brace J, Mishra DK. Polyethylene terephthalate (PET) bottle-to-bottle recycling for the beverage industry: a review. Polymers. 2022; 14(12):2366.
20. Hossain MT, Shahid MA, Mahmud N, Habib A, Rana MM, Khan SA, Hossain MD. Research and application of polypropylene: a review. Discov Nano. 2024; 19(1):2.
21. Ramya BK. Effect of various extracts of Justicia gendarussa leaves on neuropharmacological behavior activity in MPTP induced mice model. Res J Pharm Technol. 2020; 13(12):5793-5798.
22. Wongjirakitt S, Phokern N. Effectiveness of Justica gengarussa Burm. f. [Kraduk Kai Dam| Spray in Reducing Pain in the Neck-Shoulder Muscles. J Thai Trad Alt Med. 2022; 20(1):5-16.