Antidiabetic and Antidyslipidemic Activities of Dryopteris Filix-Mas Methanol Leaf Extract in Alloxan-Induced Diabetic Rats doi.org/10.26538/tjnpr/v5i12.22

Abstract

Diabetes mellitus, a chronic metabolic disease with significant morbidity and mortality, has been associated with changes in lipid profile. Dryopteris filix-mas has been widely explored in treatment and management of various disorders. The antidiabetic and antidyslipidemic effects of Dryopteris filix-mas in alloxan-induced diabetic rats were investigated in Wistar rats. Thirty (30)adults male Wistar rats used were grouped into: 1 (Normal control); 2 (Untreated alloxan induced-diabetic rats); 3 (Diabetic rats administered 500mg/kg metformin); 4 (Diabetic rats administered 100mg/kg Dryopteris filix methanol leaf extract). 5 (Diabetic rats administered 250mg/kg Dryopteris filix methanol leaf extract); 6 (Diabetic rats administered 500 mg/kgDryopteris filix methanol leaf extract). The rats were sacrificed after 21 days. The serum was used for biochemical assay of glucose, cholesterol, triglyceride, high density lipoprotein (HDL)and low-density lipoprotein (LDL), using standard procedures. Dryopteris filix leaf extract significantly (p<0.05) reduced blood glucose levels in rats after initial increase in glucose following diabetes induction. Induction of diabetes in rats significantly (p<0.05) increased serum cholesterol, triglyceride and LDL levels, while significantly reducing HDL levels in diabetic rats. However, administration of varying doses of Dryopteris filix-mas extract significantly (p<0.05) decreased levels of cholesterol, triglyceride and LDL with corresponding increase in level of HDL. The observed changes compared well with the group administered metformin.mThe methanol leaf extract of Dryopteris filix-mas, thus, improved serum lipid profile, in diabetic rats, along with having antihyperglycemic activity.